NELL'ARTROSI E NELL'ARTROSI EROSIVA
GGGs in therapy of tibiofibular
osteoarthritis of the knee. Rovetta G.
Drugs under Experimental and Clinical
Research, 17, 1, 1991.
2- Osteoartrosi erosiva, infiammatoria
e anchilosante delle mani. Rovetta G.,
Bianchi G., Monteforte P., Ghirardo G.,
Bruzzone M., Buffrini L. Riv. It. Biol.
Med. 13: 79-175, 1993.
3- Joint failure in erosive osteoarthritis
of the hands. Rovetta G, Bianchi G,
Monteforte P. Int J Tiss Reac XVII,
4- 1000 pazienti osteoartrosici
in trattamento con GGGs: valutazione
del dolore articolare. Monteforte P,
Guglielmi L, Innocenti M, Rovetta G.
Min. Med., 86, 175-180, 1995.
sulfate in erosive osteoarthritis
of the hands: early diagnosi,
early treatment. Rovetta G,
Monteforte P. In. J. Tiss.
React. XVIII (1) 43-46, 1996.
6- Rapidly destructive interphalangeal
osteoarthritis of the hands
Rovetta G. Jap J Rheum. 1996;
6, 2: 155-168.
7- Quantitative ultrasound of the
proximal phalanges: reproducibility
in erosive and nodal osteoarthritis
of the hands. Rovetta G, Battista S,
Brignone A, Monteforte P., Int J
Tissue React. 1999;21(4):121-7.
8- Chondrotinsulfate in erosive
osteoarthritis of the hands. Rovetta G,
Monteforte P., Molfetta G., Balestra V.
Int J Tissue React 2002 XXIV (1)
73-76 . l
DELL'ARTROSI EROSIVA DELLE MANI CON GGGs
G Monteforte P Int-J-Tissue-React. 1996; 18(1): 43-6
sulfate in erosive osteoarthritis of the hands: early diagnosis,
study examined the effect of an oral chondroprotective drug,
galactosaminoglycuronglycan sulfate (GAGs), on the evolution
of erosive osteoarthritis of the hands (EOA). Twenty-four
patients affected with EOA of the hands were evaluated.
The patients had painful, frank arthritis of DIP and PIP
joints; X-rays reduced joint space; X-rays central joint
erosions; positive joint scintiscan, in absence of other
inflammatory and erosive arthropathies. Twelve patients
were treated with a chondroprotective drug, GAGs 800 mg/
die; twelve patients were the control group. The results
at two years documented that the GAGs treatment influenced
certainly joint pain and doubtfully bone scintiscan in EOA.
J Tissue React 2002;24(1):29-32 Related Articles, Books,
sulfate in erosive osteoarthritis of the hands.
G, Monteforte P, Molfetta G, Balestra V.
of Rheumatology, DISEM, University of Genova Medical School,
aim of this study was to evaluate the joint count for erosions
in patients with erosive osteoarthritis (EOA) of the hands
treated with 800 mg/day of orally administered chondroitin
sulfate plus naproxen, compared with that of patients administered
naproxen only. Twenty-four consecutive patients (22 women
and two men, mean age 53.0 +/- 6) suffering from symptomatic
OA and with radiographic characteristics of EOA were studied.
The patients were divided into two groups of 12 patients
each. The first group took naproxen 500 mg/day only. The
second group was treated with chondroitin sulfate 800 mg/day
orally plus naproxen 500 mg/day. Radiological hand examinations
were performed at baseline and again after 12 and 24 months.
In both groups, the joint count for erosions showed a general
tendency to increase over time. Progression of erosions
at 24 months was lower in patients treated with 800 mg/day
chondroitin sulfate plus naproxen than in patients taking
naproxen only (p <0.05). Chondroitin sulfate failed to
stop the usual time-associated progression in the number
of finger joints presenting erosions in EOA of the hands.
It was, however, associated with a lower increase in the
number of finger joints with erosions detected after 2 years
of radiological observation.